Trump derangement syndrome ($TDS) is a pejorative term, usually for criticism or negative reactions to former United States president Donald Trump that are perceived to be irrational and to have little regard towards Trump's actual policy positions, or actions undertaken by his administration.

The term has mainly been used by Trump supporters to discredit any criticism of him, as a way of reframing the discussion by suggesting that his opponents are incapable of accurately perceiving the world.